MEXICO CITY, MEXICO 
Cruzvillegas was grew up in Ajusco, a district in the south of Mexico City. He studied Philosophy and Art at the National Autonomous University of Mexico (UNAM). He later became a professor and went on to teach Art History and Theory at UNAM.
As a sculptor and writer, Cruzvillegas began as a central participant in a new wave of conceptual art in Mexico City during the 1980s and 90s, studying under Gabriel Orozco from 1987 to 1991. Orozco has been proposed as the "dominant influence" on his work. Along with Orozco, Damian Ortega, Dr Lakra, and Minerva Cuevas, Cruzvillegas was considered part of a new movement in Latin American art (which has been compared to the YBA boom in Britain in the 1980s. or the Modernist movement of the 1920s ).
Together with Gabriel Kuri, Lakra and Orozco, he participated in "Friday Workshops" (Taller de los Viernes) in the 1980s, a weekly meeting in which the artists met and collaborated. As Cruzvillegas explained in the exhibition catalogue for 'Escultura Social: A New Generation of Art from Mexico City (2007): "We learned together to discuss, criticise, and transform our work individually, with no programmes, marks, exams, diplomas or reprisals. We did not intend to become known, prepare for a show, go against the grain, make our presence felt as a group, or even make work … this was my education". This then developed into the artist-run space "Temistocles 44" in the 1990s, founded by Eduardo Abaroa and Cruzvillegas. His works have been shown throughout America, Europe and Mexico. Elements of the Autoconstrucción project were shown (amongst others) at Tate Modern in March 2012, in the Museum of Modern Art in Oxford in 2011, at the Walker Art Center in 2013, and at the Haus der Kunst, Munich in 2014. His work is held in a number of collections, including Tate Modern, London and MoMA, New York.